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    Genetic Testing..

    I ordered the 23andme kit. I was originally going to get my full genome sequenced, but I can't afford that at this time. I was then going to wait, but the situation is urgent enough that I need to do something now. So, I'm going with the 23andme kit until I'm working again (and making money) and am able to afford something more comprehensive. I know many SNPs don't have any research associated with them, but the idea is to get the entire thing done once, such that I can continually refer back to it as time goes by.

    Has anyone gotten genetic testing done? What were your results? Were any predispositions discovered? Which? Have you tried uploading the raw data to prometheus, genetic genie, or some other site? Are there other sites/tools out there that I'm not aware of? Where's the best place to get my full genome sequenced (such that I know it's entirely done (+ brain + mitochondria + etc) after spending that massive amount of money, and that I'll never have to do it again)?

  2. #2
    BIOTCH
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    Wut is ur urgent situation? And yea there's not a lot of research, this is a new frontier. Mine confirmed food intolerances relating to SNPs but not to the specific problems I was having, it's one piece of the puzzle.

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    Senior Member BarIII's Avatar
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    I want to have this done eventually. I think they'll eventually be looking for volunteers and it will be free. I put this in my notes about a year ago:

    keywords: genetic, gene, study, medical

    http://acd.od.nih.gov/reports/DRAFT-...1-2015-508.pdf

    page 37:
    "Direct volunteers could be recruited through a number of technologies, such as internet, social media, and mobile technologies. See Section 4 for Participant Engagement recommendations."

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    Homo siderius Sistamatic's Avatar
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    Quote Originally Posted by BIOTCH View Post
    Wut is ur urgent situation? And yea there's not a lot of research, this is a new frontier. Mine confirmed food intolerances relating to SNPs but not to the specific problems I was having, it's one piece of the puzzle.
    One piece of the puzzle is an apt way of putting it.

    To expand on your point:

    Even if you had your entire genome sequenced and reviewed by the world's foremost experts, it would tell you very little that would not have to be verified by a physical exam. There are precious few alleles that act in a clear cut and binary manner, and the expression of your genetic material is affected by the environment in which the genes are expressed, and that environment includes the rest of your own genome, an environment which is utterly unique to you and which is therefore an untested circumstance for each and every one of your genes, and is, in fact, an environment for which it is very difficult to have unbiased and controlled tests. This is why personal physicians must be great detectives.

    You could, for example, determine via genetic sequencing that you are somewhat more likely than other members of the population to have an irritable bowel, or that you are a few percentage points more likely to express the symptoms attributed to celiac's disease when you consume gluten, or that you have a 64% chance of having brown eyes, or that you are very likely to have a certain blood type. While that is all incredibly fascinating (I do enjoy pouring over my 23 and me results) you will still get better information about what traits you have by observing them, either in a mirror or via diagnostic tests.

    The value of these genetic tests lies not in the data given to the individuals, but in the aggregation of many individuals' data in the hands of scientists that can be used to determine the root causes of diseases and in turn to develop treatments, all of which in the hands of a medical professional can be used to fill in more of an individual's diagnostic puzzle along with that individual's personal genetic data, but it is important that one does not lose sight of the fact that a genetic proclivity is not a smoking gun and that almost every symptom imaginable has a google of possible causes, none of which can be ruled out merely by a genetic proclivity in another direction.

    *provided that you do not have an identical twin, and even then, the environment in which the once identical genomes express themselves differs from the moment the zygote separates and therefore cannot be expected to give rise to the same traits. In fact, in some cases, the presence of a twin can cause an allele to express in an opposite manner to what it would have if a twin had been absent. For example, the hand clasping gene. Often identical twins will express opposite traits in spite of having the same allele configuration because the signal that causes the hand to develop in such a way that a particular thumb is on top when your hands are clasped is believed to be caused by an early body patterning signal that is directional, and therefore expresses oppositely in two developing embryos that are adjacent. This early opposite body patterning signaling can be so extreme in some cases that twins can have their entire internal viscera develop as mirror images of one another resulting in one twin having the condition situs reversis. The whole thing confounds the hell out of the statistics in identical twins studies involving any trait that has any origin in any early embryonic signal that is directional in nature, and it isn't as if there is a list of what those traits are. Point being, even a slight environmental difference can have a profound effect on gene expression.
    Last edited by Sistamatic; 09-05-2016 at 04:02 AM.
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    singularity precursor Limes's Avatar
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    My grandparents are like a patchwork of British flags, with England, Wales, Northern Ireland, and Scotland represented.
    It would be interesting to see whose genes won majority in the genetic battlefield that was my creation. I don't think it's England's, my dad and his dad were both 5'5" and shared a lot of traits, for starters.

    If I were black, I would be interested in which part of Africa, apparently that's the biggest use the tech has so far, just pinpointing groups with whom you share the most traits. I wonder about the algorithm they're using, if it's selective, cherry picked data, or empirically alleles from one locale.

    Sometimes, in Atlanta, you can actually see those genes, like girls with really long shins and rounded bubble butts, like the girls that Leni Riefenstahl photographed, ah yes, the Nuba. Sometimes you might see this Nuba girl, <David Attenborough> gracefully making her way down the terminal, having stalked the newly arriving passengers for predators. Her walk has been selected by predation and natural selection in defense of predators</DA> and her buttocks have a 40 year, sag free, guarantee.

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    Quote Originally Posted by Sistamatic View Post
    One piece of the puzzle is an apt way of putting it.

    To expand on your point:

    Even if you had your entire genome sequenced and reviewed by the world's foremost experts, it would tell you very little that would not have to be verified by a physical exam. There are precious few alleles that act in a clear cut and binary manner, and the expression of your genetic material is affected by the environment in which the genes are expressed, and that environment includes the rest of your own genome, an environment which is utterly unique to you and which is therefore an untested circumstance for each and every one of your genes, and is, in fact, an environment for which it is very difficult to have unbiased and controlled tests. This is why personal physicians must be great detectives.

    You could, for example, determine via genetic sequencing that you are somewhat more likely than other members of the population to have an irritable bowel, or that you are a few percentage points more likely to express the symptoms attributed to celiac's disease when you consume gluten, or that you have a 64% chance of having brown eyes, or that you are very likely to have a certain blood type. While that is all incredibly fascinating (I do enjoy pouring over my 23 and me results) you will still get better information about what traits you have by observing them, either in a mirror or via diagnostic tests.

    The value of these genetic tests lies not in the data given to the individuals, but in the aggregation of many individuals' data in the hands of scientists that can be used to determine the root causes of diseases and in turn to develop treatments, all of which in the hands of a medical professional can be used to fill in more of an individual's diagnostic puzzle along with that individual's personal genetic data, but it is important that one does not lose sight of the fact that a genetic proclivity is not a smoking gun and that almost every symptom imaginable has a google of possible causes, none of which can be ruled out merely by a genetic proclivity in another direction.

    *provided that you do not have an identical twin, and even then, the environment in which the once identical genomes express themselves differs from the moment the zygote separates and therefore cannot be expected to give rise to the same traits. In fact, in some cases, the presence of a twin can cause an allele to express in an opposite manner to what it would have if a twin had been absent. For example, the hand clasping gene. Often identical twins will express opposite traits in spite of having the same allele configuration because the signal that causes the hand to develop in such a way that a particular thumb is on top when your hands are clasped is believed to be caused by an early body patterning signal that is directional, and therefore expresses oppositely in two developing embryos that are adjacent. This early opposite body patterning signaling can be so extreme in some cases that twins can have their entire internal viscera develop as mirror images of one another resulting in one twin having the condition situs reversis. The whole thing confounds the hell out of the statistics in identical twins studies involving any trait that has any origin in any early embryonic signal that is directional in nature, and it isn't as if there is a list of what those traits are. Point being, even a slight environmental difference can have a profound effect on gene expression.
    Well, I don't need black and white absolute yes/no indicators. I just need hunches, leads, good theories, suggestions, etc. I think genetic testing, hair sample analysis, and blood testing will be provide good information to help me try to "figure it all out." Unless the genetic results end up being correlated to or suggestive of nothing.

    It would also be good to have the sequencing out of the way, such that when new research/findings are shared, I can just look up my "sequence" to see what it implies for me. Also, it allows me to do research of my own (maybe) or to potentially make better decisions about what routes to take, supplements to try out, etc. For example, I'm wondering which COMT polymorphism I have (Val/Val, Val/Met, or Met/Met). If I can figure this out, then it would strongly suggest if I should look into amphetamine salts, modafinil, etc, or if they'll likely be a waste of time. It will also suggest how I should take them to maximize their effects and the chances they'll have an effect. I'm also wondering if I have (over/under) methylation issues or a predisposition to pyroluria (extra pyrroles from hemoglobin synthesis that (are harmless but) bind to vitamin B6 and zinc, resulting in a deficiency of both). Some of these things I can somewhat infer based on symptoms, but it's gotten to the point that I want explicit polymorphisms/sequences/whatever in front of me, such that I can see WTF is going on. Too much guessing, too many things in the air, and after realizing I had a magnesium deficiency, I'm now trying to find blanket/general approaches to see if there are other issues I'm not aware of. I could've gotten a test for vitamin B6 levels (and zinc), but for some reason, I can't find them on the lab form at the doctor's office. It's extremely infuriating not to be able to just have my levels (accurately) checked all around, but I just keep going.

    I'm also curious about my ethnic heritage (I'm black, but as my mother's father seemed to be a mixture of things, I'm curious to find out what that is), and if I have any "special" genes (the positive ones).

  7. #7
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    I just realized this does explain my nose and especially my mouth. The mouth is weird.

    I thought about this a bit more. Being a "Melungeon" in any way is basically considered as "Human feces, in part." I've heard the jokes. It's so ridiculous. Just combine Appalachian VA, Sub-Saharan African, Native American, and a family cluster that goes back to the 1600's or 1700's

    My dad's entire family lived in two or three counties in NC since the 1600's. Oh my. Outcross, stat!

    My maternal grandmother was technically a "Melungeon" (an ugly word ). I knew we had a tiny percentage of Sub-Saharan African ancestry on her side, but I recently found out that there's a bit of Native American too. So, the trifecta is complete. I am mixed race and very inbred on my maternal grandmother's side. My maternal grandfather was Irish and German.

    My aunt showed me which test it was, but I've forgotten.

    The maternal grandmother breakdown was funny.

    I don't remember the order, but it was something like this:

    Northern European
    UK and British Isles
    French
    German
    Eastern European ?
    Finland
    Italian
    Sub-Sarahan
    Native American (Cherokee, I assume)



    https://en.wikipedia.org/wiki/Melungeon

    Melungeon (/məˈlʌndʒən/ mə-lun-jən) is a term traditionally applied to one of numerous "tri-racial isolate" groups of the Southeastern United States. Historically, Melungeons were associated with the Cumberland Gap area of central Appalachia, which includes portions of East Tennessee, Southwest Virginia, and eastern Kentucky. Tri-racial describes populations thought to be of mixed European, African and Native American ancestry. Although there is no consensus on how many such groups exist, estimates range as high as 200.[1][2] Melungeons were often referred to by other settlers as of Portuguese or Native American origin.

    [...]

    The term Melungeon was traditionally considered an insult, a label applied to Appalachian whites who were by appearance or reputation of mixed-race ancestry, though who were not clearly either "black" or "Indian". In southwest Virginia, the term Ramp was similarly applied to people of mixed race. This term has never shed its pejorative character.[38] In December 1943, Virginia State Registrar of Vital Statistics, Walter Ashby Plecker, sent county officials a letter warning against "colored" families trying to pass as "white" or "Indian" in violation of the Racial Integrity Act of 1924 and mentioned by county specific surnames, including: "Lee, Smyth and Wise: Collins, Gibson, (Gipson), Moore, Goins, Ramsey, Delph, Bunch, Freeman, Mise, Barlow, Bolden (Bolin), Mullins, Hawkins (chiefly Tennessee Melungeons)".[39] (Lee County, Virginia borders Hancock County, Tennessee.)

    According to the principle of partus sequitur ventrem, which Virginia incorporated into law in 1662, children were assigned the social status and ethnicity of their mother, regardless of their father's ethnicity or citizenship. This meant the children of African slave mothers were born into slavery. But it also meant the children of free white or mulatto women, even if fathered by enslaved African men, were born free. The free descendants of such unions formed many of the oldest free families of color. Early colonial Virginia was very much a "melting pot" of peoples, and some of these early multiracial families were ancestors of the later Melungeons. Each family line has to be traced separately. Over the generations, most individuals of the group called Melungeon were actually people of European and African descent, whose ancestors had been free in colonial Virginia.[8]

    Edward Price's dissertation on "Mixed-Blood Populations of the Eastern United States as to Origins, Localizations, and Persistence" stated that children of European and free black unions had intermarried with persons of Native American ancestry. These conclusions have been largely upheld in subsequent scholarly and genealogical studies. In 1894, the U.S. Department of the Interior, in its "Report of Indians Taxed and Not Taxed," noted that the Melungeons in Hawkins County "claim to be Cherokee of mixed blood".[3] The term Melungeon has since sometimes been applied as a catch-all phrase for a number of groups of mixed-race ancestry. In 2012, the genealogist Roberta Estes and her fellow researchers reported that the Melungeon lines likely originated in the unions of black and white indentured servants living in Virginia in the mid-1600s before slavery became widespread.[5] They concluded that as laws were put in place to prevent the mixing of races, the family groups could only intermarry with each other. They migrated together from western Virginia through the Piedmont frontier of North Carolina, before settling primarily in the mountains of East Tennessee.[10]
    Dad was mostly English, with some French and Irish



    And I just realized that my heritage makes me a target for jokes. In so many ways. I look European. My mom does as well, but she has aqua blue eyes and olive skin. Dad was as white as a sheet.
    Last edited by Lurker; 09-05-2016 at 07:37 AM.


  8. #8
    Homo siderius Sistamatic's Avatar
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    Quote Originally Posted by baccheion View Post
    Well, I don't need black and white absolute yes/no indicators. I just need hunches, leads, good theories, suggestions, etc. I think genetic testing, hair sample analysis, and blood testing will be provide good information to help me try to "figure it all out." Unless the genetic results end up being correlated to or suggestive of nothing.

    It would also be good to have the sequencing out of the way, such that when new research/findings are shared, I can just look up my "sequence" to see what it implies for me. Also, it allows me to do research of my own (maybe) or to potentially make better decisions about what routes to take, supplements to try out, etc. For example, I'm wondering which COMT polymorphism I have (Val/Val, Val/Met, or Met/Met). If I can figure this out, then it would strongly suggest if I should look into amphetamine salts, modafinil, etc, or if they'll likely be a waste of time. It will also suggest how I should take them to maximize their effects and the chances they'll have an effect. I'm also wondering if I have (over/under) methylation issues or a predisposition to pyroluria (extra pyrroles from hemoglobin synthesis that (are harmless but) bind to vitamin B6 and zinc, resulting in a deficiency of both). Some of these things I can somewhat infer based on symptoms, but it's gotten to the point that I want explicit polymorphisms/sequences/whatever in front of me, such that I can see WTF is going on. Too much guessing, too many things in the air, and after realizing I had a magnesium deficiency, I'm now trying to find blanket/general approaches to see if there are other issues I'm not aware of. I could've gotten a test for vitamin B6 levels (and zinc), but for some reason, I can't find them on the lab form at the doctor's office. It's extremely infuriating not to be able to just have my levels (accurately) checked all around, but I just keep going.

    I'm also curious about my ethnic heritage (I'm black, but as my mother's father seemed to be a mixture of things, I'm curious to find out what that is), and if I have any "special" genes (the positive ones).
    You must use the browse raw data feature in 23 and me to see these sorts of things, which means you must know what you are looking for in order to find it.

    If you decide to do 23 and me, just put rs4680 into your "browse raw data" search and you'll get your snp. (Assuming you are talking about variations of codon 158 in the COMT gene...which has other codons that can also vary.) Note how the following article and any other peer reviewed article on the subject uses "may" to equivocate almost every single statement it makes. https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract).

    I'm G/G, which codes for Val/Val.
    Insults are effective only where emotion is present. -- Spock, "Who Mourns for Adonais?" Stardate 3468.1.

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  9. #9
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    Quote Originally Posted by Sistamatic View Post
    You must use the browse raw data feature in 23 and me to see these sorts of things, which means you must know what you are looking for in order to find it.

    If you decide to do 23 and me, just put rs4680 into your "browse raw data" search and you'll get your snp. (Assuming you are talking about variations of codon 158 in the COMT gene...which has other codons that can also vary.) Note how the following article and any other peer reviewed article on the subject uses "may" to equivocate almost every single statement it makes. https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract).

    I'm G/G, which codes for Val/Val.
    Yes, I know I have to know what I'm looking for, but I plan on learning and also on uploading the data to sites like http://geneticgenie.org/ and Promethease.

    It's good you know you have the Val/Val COMT polymorphism! That strongly suggests you should avoid Marijuana (as it's more likely to cause psychosis, paranoia, hearing voices, etc), and that you may be more prone to addiction and mental illness. It also points to a deficient dopamine production system (the main reason I want to know which I am) that is the prime example of what amphetamine salts (like Adderall) are about treating. That is, your IQ and motivation levels will significantly/noticeably benefit from enhancing dopamine levels. You should have a good amount of tolerance, as you're restoring/normalizing dopamine levels, rather than trying to raise them past what they'd typically be. That is, I strongly recommend you look into Modafinil, Nuvigil, or Adrafinil, the over the counter version! It's as though that product was made for people like you.

    You can upload your raw data to https://promethease.com/ (other resources: https://www.snpedia.com/index.php/SNPedia -- what are your results for the more popular SNPs?) to see if it can uncover any other similar insights/recommendations. Maybe it will help you more intelligently choose what to supplement with, to realize benefits you hadn't thought of (or thought possible).

    For one, I'm very curious now (especially as you're an INTP) how well you'll respond to dopamine enhancers. You can read more about the Val/Val genotype and dopamine here: https://selfhacked.com/2014/12/24/wo...mt-v158m-gene/

    (It also biases you toward being better with languages than math, to having increased verbal fluidity (if female; decreased if male), to having poorer functioning working memory, a higher tolerance for pain, more difficulty ignoring outside stimulus/distractions when trying to concentrate, more easily hypnotized (would benefit from brainwave entrainment with a program like Neuro-Programmer 3), etc).

    Here's my beginner stack recommendation (if you don't want to get Modafinil, Nuvigil, or Adrafinil (the non-prescription precursor)):

    - 75mg PhenylPiracetam Hydrazide
    - 15-30mg Fasoracetam
    - 1-2g Acetyl L-Carnitine
    - N-Acetyl L-Tyrosine
    - 500mg Centrophenoxine
    - 2g Fish Oil
    - TheaCrine (or regular caffeine if too expensive)

    You would only be able to take that combo once or twice per week (to avoid tolerance), but when you do take it, you should notice significant positive improvements in many areas (Val/Val leaves you practically screaming to be fed with this stuff).
    Last edited by baccheion; 09-05-2016 at 06:55 PM.

  10. #10
    Homo siderius Sistamatic's Avatar
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    Quote Originally Posted by baccheion View Post
    Yes, I know I have to know what I'm looking for, but I plan on learning and also on uploading the data to sites like http://geneticgenie.org/ and Promethease.

    It's good you know you have the Val/Val COMT polymorphism! That strongly suggests you should avoid Marijuana (as it's more likely to cause psychosis, paranoia, hearing voices, etc), and that you may be more prone to addiction and mental illness. It also points to a deficient dopamine production system (the main reason I want to know which I am) that is the prime example of what amphetamine salts (like Adderall) are about treating. That is, your IQ and motivation levels will significantly/noticeably benefit from enhancing dopamine levels. You should have a good amount of tolerance, as you're restoring/normalizing dopamine levels, rather than trying to raise them past what they'd typically be. That is, I strongly recommend you look into Modafinil, Nuvigil, or Adrafinil, the over the counter version! It's as though that product was made for people like you.

    You can upload your raw data to https://promethease.com/ (other resources: https://www.snpedia.com/index.php/SNPedia -- what are your results for the more popular SNPs?) to see if it can uncover any other similar insights/recommendations. Maybe it will help you more intelligently choose what to supplement with, to realize benefits you hadn't thought of (or thought possible).

    For one, I'm very curious now (especially as you're an INTP) how well you'll respond to dopamine enhancers. You can read more about the Val/Val genotype and dopamine here: https://selfhacked.com/2014/12/24/wo...mt-v158m-gene/

    (It also biases you toward being better with languages than math, to having increased verbal fluidity (if female; decreased if male), to having poorer functioning working memory, a higher tolerance for pain, more difficulty ignoring outside stimulus/distractions when trying to concentrate, more easily hypnotized (would benefit from brainwave entrainment with a program like Neuro-Programmer 3), etc).

    Here's my beginner stack recommendation (if you don't want to get Modafinil, Nuvigil, or Adrafinil (the non-prescription precursor)):

    - 75mg PhenylPiracetam Hydrazide
    - 15-30mg Fasoracetam
    - 1-2g Acetyl L-Carnitine
    - N-Acetyl L-Tyrosine
    - 500mg Centrophenoxine
    - 2g Fish Oil
    - TheaCrine (or regular caffeine if too expensive)

    You would only be able to take that combo once or twice per week (to avoid tolerance), but when you do take it, you should notice significant positive improvements in many areas (Val/Val leaves you practically screaming to be fed with this stuff).
    I can see that you are very excited about my genotype, so I almost feel bad that I don't share your enthusiasm. Thing is, I don't want to change. I've got my whole world arranged to work for the person I already am. What if these drugs do everything you say they will? I don't want to turn into some kind of ultra efficient ambitious go getter, and while nothing would make my mother in law happier, I think my husband would probably miss the old me. I want to ride my bike and dream and tell stories and play in the sand and figure out how things work, and I'm good at all that stuff already. It seems to me that changing the way I think would cause me to lose as much as I'd gain. I don't think one way is better than the other, but rather that it takes all types. I am me and that's a good thing, and you are you, and that's a good thing too.

    I do try to get good nutrition via food (i.e. fish oil by eating fish, eat veggies alot, avoid processed foods except when they are really tasty and right there and free like lemon cream filled donuts in the break room...fuck impulse control. I mean are you offering to make me not want donuts anymore? Give me donuts or give me death. (but, you know, allow me enough control over my environment that impulse control is not a constant issue....like, don't buy a bunch of donuts and put them in the kitchen where no one will know except me if I eat all of them. Get in my belly, donuts!)

    Plus what we are talking about here is only one of many genes. It doesn't tell my whole story. If you take every Val Val and average these traits and compare them to the average of every met/met and every val/met, you can see trends that are indicative of the possible effects of these genes, but in an individual, all bets are off.

    I'm 45 years old so I've got a good bit of past personal anecdote on the traits you've listed. I know myself pretty well at this point and I'm pretty good at hacking my problem traits when I want to. That's really the only satisfaction I can vicariously offer you.

    I've experimented with a great many extremely addictive things (decades ago and I will offer no details on the internet), and the only one that stuck was caffeine (dear god, the caffeine I consume...but I can quit anytime I want...please let there always be caffeine in my life). I quit nicotine cold turkey 15 years ago.

    When I was in my 20s, I smoked pot a lot and I didn't have any psychotic episodes as a result. Been there, done that, meh. Not worth the potential trouble now. If it was legal I might ingest it here and there, but mostly it just makes my day go by without me.

    I have an excellent working memory. Or if I don't, I don't realize it. I remember every single thing that I remember to remember. I do suck at typing long strings of random digits into the phone during automated calls unless it is a number I know by heart. I never manage to do it fast enough that it won't assume I've failed and forward me to a live person. But maybe everyone has that problem. I'm not overly concerned though.

    I have a lot of trouble ignoring outside distractions. VR desktop to the rescue! (seriously, VR and a good set of noise canceling headphones eliminates the shit out of distractions) Plus I have a study in my home that is all me and only me with a door that closes and sound absorbing foam and everything. But when I'm out in the world in data gathering mode I notice a lot of things other people don't, and ignore a lot of things other people see. I don't think that's a bad thing. I don't want to change it.

    I seriously doubt I could be hypnotized unless I wanted to be, and I cannot imagine a scenario in which that would be the case. I was that one person in a lineup of audience volunteers for a stage hypnotist who boringly refused to cluck like a chicken on camera. My date accused me of being a bad sport by not playing along, but I think he was just mad because he clucked like a chicken and I didn't. I suspect stage hypnotists are just people who can socially leverage others into playing along and who can pick people out of a crowd who will play along. This hypnotist did not pick me. He picked my date and my date dragged me along.

    I'm extremely good at both math and language, as measured in standardized tests (99th percentile in language on GRE, perfect scores on math tests in college that almost everyone else failed, etc. 99th percentile in every category on the ASVAB except clerical...60th percentile there. I must have gotten distracted by an outside stimulus, ha) and as reflected in my relative standing in graduate courses that centered on the same. The problem with 99th percentiles in two things is that it becomes impossible to tell which of the two things I am relatively better at. I'll say it's probably verbal...but if you had asked me in college when I was taking math classes, I'd have said math. In any case, my potential has never been the limiting factor in any of these things.

    My IQ when it was measured in grade school was very high -- high enough that making it higher would probably make me feel lonely, especially if you consider that I've built a social network and all of my relationships around being the person I already am. I've got zero interest in knowing what it is now. I rather hope my IQ has gone down because it would be a positive thing if I was wrong about how I see the rest of the world.

    I am certain that if I was more ambitious and focused I'd have gone further down the paths I was distracted from when I was in school, but I'd have missed out on all the things that distracted me and I wouldn't trade all of that for anything.
    Insults are effective only where emotion is present. -- Spock, "Who Mourns for Adonais?" Stardate 3468.1.

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