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Thread: Do black people metabolize codeine differently

  1. #1
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    Do black people metabolize codeine differently

    Compared to white people

    Generally

  2. #2
    Senior Member BarIII's Avatar
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    Feb 2015
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    I guess, based on this, but I don't know what everything means:

    The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity.

    OBJECTIVE:

    The effects of the CYP2D6*17 and *29 alleles on substrate specificity and enzyme activity were studied by correlating CYP2D6 genotype to phenotype with 4 probe drugs (codeine, debrisoquine, dextromethorphan, metoprolol) in black Tanzanians and white Swedes.



    CONCLUSION:

    We found differences in the disposition of 4 CYP2D6 probe drugs in black Tanzanians compared with Swedes. The differences were caused by the presence of CYP2D6.17 and CYP2D6.29. The results show that CYP2D6.17 exhibits altered substrate specificity compared with CYP2D6.1 and CYP2D6.2.
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